EZ-USB HX2 (CY7C65640A) is now Not Recommended for New Designs.
Cypress TetraHub™ is a high performance Multiple Transaction Translator (TT) USB2.0 hub controller. Each downstream port of the TetraHub has its own transaction translator to provide the best USB performance no matter what class of USB device is connected it. TetraHub is ideal for applications that need guaranteed performance on each downstream port.
Find the migration document from TetraHub to HX2VL here - AN69235